Data mining, bioinformatics, computational modeling and simulation have increasingly become integral to development of novel hypotheses in disease progression and potentially novel therapeutic innovations. Recent development of dynamic algorithms that allow rapid analysis of publicly available datasets directly relevant to childhood leukemia provide a unique opportunity for a biomedical revolution that can provide the foundation for therapeutic innovations aimed at eradicating childhood leukemia utilizing more specifically defined targets exhibiting more favorable toxicity profiles. My research seeks to take advantage of these opportunities to train independent and creative scientists who in a collaborative environment are capable in tackling complex diseases such as cancer. We have gained unprecedented molecular detail in the emergence and progression of cancer cells through the development of many high-throughput technologies and the query of these datasets in curated databases to envision a new paradigm of therapeutic innovations. As we increase our understanding of the molecular events that result in the emergence of cancer cells, we hope to be able to target these cells at the earliest of stages employing novel nano-technology platforms. I have active collaborations with the Children’s Hospital Los Angeles and the National Cancer Institute Alliance for Nanotechnology in Cancer with aims to integrate Bioinformatics, Computational Biology with development of novel nano-particles to target childhood leukemias.
Peer reviewed Publications with Students.
Jason J. Pitt and Sanjive Qazi. “Phenotypes for Prediction: Gene Expression and Genetic Exceptionalism.” eJournal of Biological sciences Volume 2, Issue 1 (January-March, 2010) pp 52
Sanjive Qazi, N. L. Soiseth and F. M. Uckun. “Early Detection of Subtype-Specific HIV-1 Infection Using Transcriptomes from Host Cell Responses.” eJournal of Biological sciences Volume 2, Issue 1 (January-March, 2010) pp 65.
Uckun FM, Pitt J, Qazi S. JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia. (2011). Expert Rev Anticancer Ther. Jan;11(1):37-48. Epub 2010 Nov 11. Review
Uckun FM, Qazi S, Ozer Z, Garner AL, Pitt J, Ma H, Janda KD (2011). Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. Br J Haematol. Jun;153(6):741-52.
Conference presentations with students.
Nicole Soiseth and Laura Secor entitled “RELATION BETWEEN GENE SIGNALING EVENTS IN HIV-1 INFECTION AND CANCER PROLIFERATION.” University of St. Thomas, St. Paul, Minnesota Academy of Science. 2010
Ann Bergstrand, Dawn Comstock, Ryan Schmidtman, Jamison Utzig entitled “Bioinformatics analysis of HIV’s regulation of NF-kB.” University of St. Thomas, St. Paul, Minnesota Academy of Science. 2010
James Ebeling and Kimberly Rostvold entitled “GENE EXPRESSION CONNECTIONS BETWEEN HIV-1 VIRUS INFECTION AND NEURODEGENERATIVE DISEASES.” University of St. Thomas, St. Paul, Minnesota Academy of Science. 2010
Ashley Baumann, Becky Dove, Jeanifer Poon entitled “Design of patient-tailored therapies using multiple holistic treatments to reduce stress indicators.” 24th National Conference on Undergraduate Research. Montana. 2010
Directed Research Courses with students.
Special Honors Thesis Adviser: "Medicine can be Learned but not Taught" (Dawn Comstock, 2013)
Bio391: "Benefits of Employing Alternative Therapies in the Treatment of Chronic Low Back Pain" with Fadumo Mire (2012)
Bio292: "Meditative Evaluation and Measuring Stress Levels in Vulnerable Adult and Mentally Unstable Clients" with Daniel Sinda (2012)
Special Honors Thesis Adviser: Is “good” science enough for the implementation of pharmacogenomic-based research into mainstream healthcare.’ (Jason Pitt, 2009); How Much Do Science And Law Inform Reproductive Choice? A study of public opinions on prenatal genetic testing. (Kelly Broady, 2010).
J-term Credit (2012). In-silico drug trials for nano-particle delivered anti-cancer compounds with Jamison Utzig.
Bio391: “Deep Breathing Exercises and Pain Management in Oncology Patients” (2012) with Rachel Haugo.
Bio292: “Meditative Evaluation and Measuring Stress Levels in Vulnerable Adult and Mentally Unstable Clients” (2012) with Daniel Sinda.
Bio392: “Exploration of new model systems to study signal transduction relevant in cancer progression.” (2010) with James Ebeling and Dr. Kimberely Murphy.
Bio392: “Oxidative stress pathways in Breast Cancer” (2009) with Kelly Broady.
Bio391: “Detecting Positive Selection for Retroviral Insertions within the Non-coding Regions of the Human Genome via Gene Expression.” (2009) with Jason Pitt.
Bio392: “Ethical Implementation of Pharmacogenomic Discoveries within Clinical Trials.” (2009) with Jason Pitt.
Research grants awarded: Gustavus Student-Faculty Presidential Award: “Bioinformatic approaches to understanding gene switching in the model system fruit fly, Drosophila melanogaster and the hijacking of the host T-Cell machinery by HIV.” (2008) with Jason Pitt.
Bush Foundation Minigrant: Student research in Bioinformatics. (2008).
Sigma Xi Student Research Adviser: “Strategies for neural and immune responses to provide mechanistic understanding of Holistic Medicine” (2009).
Cassandra Breitenfeldt. "Physiological allostatic model of theater performance: cortisol response in actors following a performance" (2010).
Krista Primely. The voices of hidden memories and brain arousal (2011)
Gustavus Research, Scholarship and Creativity Grant: “Research strategies drawn from Affective Neuroscience and Neuro-endocrinology to provide mechanistic understanding of Holistic Therapies.” (2009)
B.S. University of Sheffield, Sheffield, U.K.; PhD, CASE Bath University, U.K.
Areas of Expertise
- SYK mediated chemo-resistance mechanism in ALL
- Gene expression in HIV diagnosis
- Gene expression Genetic Exceptionalism
- Anti-HIV compound Stampidine 1 in Mice
- Anti-HIV Compound Stampidine 2 Cell lines
- Anti-HIV compound Stampidine 3 Cats
- GABA receptor: Neural Correlate of Consciousness?
- Insect Biochemistry NO/cGMP
- Inhibition of sperm_Structure Activity
- HIV Gene expression profiling IMA presentation
- CD22 B-cell Leukemias
- JAK3 Inhibitor in Nano-particle form
- Math in Medicine Workshop_Bone cells
- ALL Infant Gene Expression
- Vinorelbine therapy ALL
- Epigenetics of Stampidine Stampidine silences HDFs
- SYK phosphorylation of Ikaros
BIO-102 (Organismal Biology Lab) and BIO-118 (Microbes and Human Health Lab)
|Synonym||Title||Times Taught||Terms Taught|
|BIO-201||Cell Biology Lab||29||2013/FA, 2012/FA, 2011/FA, 2010/FA, 2009/FA, 2008/FA, and 2007/FA|
|BIO-118||Microbes and Human Health Lab||18||2013/SP, 2012/SP, 2011/SP, 2010/SP, 2009/SP, and 2008/SP|
|BIO-201||Cell and Molecular Biology||14||2013/FA, 2012/FA, 2011/FA, 2010/FA, 2009/FA, 2008/FA, and 2007/FA|
|BIO-268||Career Exploration||10||2014/JN, 2013/JN, 2012/JN, 2010/JN, 2009/JN, and 2008/JN|
|BIO-102||Organismal Biology Lab||9||2012/SP, 2011/SP, 2010/SP, 2009/SP, and 2008/SP|
|NDL-268||Career Exploration||3||2014/JN, 2013/JN, and 2012/JN|
|BIO-392||Biology Research||3||2010/FA, 2009/FA, and 2009/SP|
|BIO-108||Neurobiology of Emotion||2||2011/JN and 2008/JN|