Sanjive Qazi

Faculty

Senior Continuing Lab Instructor in Biology

The use of bioinformatics in developing targeted therapies for high-risk leukemiasData mining, bioinformatics, computational modeling and simulation have increasingly become integral to development of novel hypotheses in disease progression and potentially novel therapeutic innovations.   Recent development of dynamic algorithms that allow rapid analysis of publicly available datasets directly relevant to childhood leukemia  provide a unique opportunity for a biomedical revolution that can provide the foundation for therapeutic innovations aimed at eradicating childhood leukemia utilizing more specifically defined targets exhibiting more favorable toxicity profiles.  My research seeks to take advantage of these opportunities to train independent and creative scientists who in a collaborative environment are capable in tackling complex diseases such as cancer.  We have gained unprecedented molecular detail in the emergence and progression of cancer cells through the development of many high-throughput technologies and the query of these datasets in curated databases to envision a new paradigm of therapeutic innovations.  As we increase our understanding of the molecular events that result in the emergence of cancer cells, we hope to be able to target these cells at the earliest of stages employing novel nano-technology platforms.  I have active collaborations with the Children’s Hospital Los Angeles and the National Cancer Institute Alliance for Nanotechnology in Cancer with aims to integrate Bioinformatics, Computational Biology with development of novel nano-particles to target childhood leukemias.

Peer reviewed Publications with Students.

Jason J. Pitt and Sanjive Qazi.  “Phenotypes for Prediction: Gene Expression and Genetic Exceptionalism.” eJournal of Biological sciences Volume 2, Issue 1 (January-March, 2010) pp 52

Sanjive Qazi, N. L. Soiseth and F. M. Uckun. “Early Detection of Subtype-Specific HIV-1 Infection Using Transcriptomes from Host Cell Responses.”  eJournal of Biological sciences Volume 2, Issue 1 (January-March, 2010) pp 65.

Uckun FM, Pitt J, Qazi S. JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia. (2011).  Expert Rev Anticancer Ther. Jan;11(1):37-48. Epub 2010 Nov 11. Review

Uckun FM, Qazi S, Ozer Z, Garner AL, Pitt J, Ma H, Janda KD (2011). Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. Br J Haematol. Jun;153(6):741-52.

Education

B.S. University of Sheffield, Sheffield, U.K.; PhD, CASE Bath University, U.K.



Courses Taught

BIO-201 (Cell Biology Lab)

Past
Synonym Title Times Taught Terms Taught
BIO-201 Cell Biology Lab 37 2018/FA, 2017/FA, 2016/FA, 2015/FA, 2014/FA, 2013/FA, 2012/FA, 2011/FA, 2010/FA, 2009/FA, 2008/FA, and 2007/FA
BIO-201 Cell and Molecular Biology 25 2018/FA, 2017/FA, 2016/FA, 2015/FA, 2014/FA, 2013/FA, 2012/FA, 2011/FA, 2010/FA, 2009/FA, 2008/FA, and 2007/FA
BIO-118 Microbes and Human Health Lab 21 2014/SP, 2013/SP, 2012/SP, 2011/SP, 2010/SP, 2009/SP, and 2008/SP
BIO-102 Organismal Biology Lab 13 2019/SP, 2016/SP, 2014/SP, 2012/SP, 2011/SP, 2010/SP, 2009/SP, and 2008/SP
BIO-268 Career Exploration 11 2017/JN, 2014/JN, 2013/JN, 2012/JN, 2010/JN, 2009/JN, and 2008/JN
NDL-268 Career Exploration 8 2019/JN, 2018/JN, 2017/JN, 2016/JN, 2014/JN, 2013/JN, and 2012/JN
BIO-218 Microbio Lab 7 2019/SP, 2018/SP, 2016/SP, and 2015/SP
BIO-108 Neurobiology: Emotions 4 2018/JN, 2016/JN, 2011/JN, and 2008/JN
BIO-392 Biology Research 4 2016/SP, 2010/FA, 2009/FA, and 2009/SP
BIO-218 Fundmental Microbio 2 2018/SP and 2015/SP
BIO-344 ST:Bioinformatics Lab 1 2018/FA
BIO-101 Principles Lab 1 2016/FA
BIO-397 Honors Thesis 1 2016/SP